Health
A long-term, large-scale study published by BMC Medicine provided further evidence that adherence to the Mediterranean diet is associated with lower dementia risk.
The results showed that participants with the highest adherence to the Mediterranean diet lower such risk by up to 23 percent. A lower adherence might still yield some beneficial effects.
Irrespective of the degree of the genetic risk, there is a beneficial pattern to adopting the Mediterranean diet… Even if you have a high genetic risk of developing dementia, you could still benefit from dietary changes.- Oliver Shannon, researcher, Newcastle University Population Health Sciences Institute
A research team from Newcastle University and other United Kingdom academic institutions assessed the impact of following the Mediterranean diet on 60,298 people with a follow-up period of more than nine years. The size and duration of the trial make it one of the most extensive studies ever conducted in this area.
“There have been a number of previous studies on the subject,” Oliver Shannon, a co-author of the study and researcher at Newcastle University’s Population Health Sciences Institute, told Olive Oil Times.
See Also:Health News“Generally, they have been small studies and did not have many dementia cases, factors that limited their statistical power to detect the possible association between the Mediterranean diet and dementia,” he added.
The researchers accessed the information from the U.K. Biobank database, an ongoing cohort study of more than 500,000 participants. The database is considered a crucial source for investigating diseases that develop in middle and older age.
By applying standard investigation methods commonly used in long-term cohort studies, U.K. scientists could identify individuals whose data were of interest for the study, including Mediterranean diet adherence.
Eight hundred eighty-two cases of dementia were reported during the 9.1‑year follow-up period in the sample group, which included individuals with an average age of 63.8 years.
Their dietary habits, body mass index, socioeconomic status, education, sleep duration and physical activity level were among the indexes considered by the research.
The extended follow-up provides researchers with a more reliable data set to study. Usually, patients who are in the early stages of developing dementia switch to a healthier diet as a consequence of that condition.
“That makes it more challenging for these kinds of studies as there is a potential issue of reverse causality,” Shannon said. “But if you can track the dietary habits for a long time, that mitigates the issue of reverse causality, as you can look at how their dietary habits were before [the dementia onset] and how they developed.”
Therefore, the researchers measured the incidence of dementia in each of the three groups into which the study subjects were divided, identified by low, moderate or high adherence to the Mediterranean diet.
“If we look at people with the lowest adherence to the Mediterranean diet, for every 1,000 people we have seen, 17 of them develop dementia during the follow-up period,” Shannon said. “In the higher Mediterranean diet intake group, instead, only 12 individuals per 1,000 developed dementia.”
In the study, the researchers highlighted how higher Mediterranean diet adherence was found among women with healthy body mass index values, higher educational levels and a higher level of physical activity compared to the group with lower adherence.
The study also investigated how individuals with a genetic predisposition for dementia respond to adopting the Mediterranean diet.
See Also:EVOO Improves Brain Protection in Cases of Mild Cognitive Impairment“That is something that very little previous research has ever looked into,” Shannon said. “We were interested to see if the impact of the Mediterranean diet differed in individuals with different genetic profiles.”
“We know that there are certain genes which might make individuals more likely to develop dementia or certain variants of those genes,” Shannon said.
For example, individuals who carry the APOE gene and its allele APOE4 are considered significantly more at risk of developing dementia.
In their study, scientists used a polygenic risk score to combine a complete set of genetic information potentially related to dementia onset and used it to profile the subjects involved in the study.
“That allowed us to explore if the impact of the Mediterranean diet would be different for people carrying a high genetic risk and people with a low genetic risk,” Shannon said.
“What we found is that irrespective of the degree of the genetic risk, there is a beneficial pattern to adopting the Mediterranean diet,” he added. “The good news is that even if you have a high genetic risk of developing dementia, you could still benefit from dietary changes.”
According to Alzheimer’s Research, a charity, approximately 944,000 people in the country have dementia. About 67 million people live in the U.K. Statistics show that in the over-65 age group, one person out of 11 has dementia.
The incidence of dementia in the country is expected to grow considerably over time, rising from one million patients in 2030 to 1.6 million expected by 2050. According to the research institute, increasing life expectancy is the driving force behind these rising figures.
Separate research published in The Lancet last year found dementia cases are expected to triple globally by 2050, rising to more than 153 million people.
The scientists said the next steps of the research would investigate whether the Mediterranean diet can be used as a tool for intervention against dementia. Such a study would assess the dementia outcomes of groups of people following different diets.
“Rather than just looking at the interactions and the associations, we hope in the coming years to be researching whether it is possible to intervene with the Mediterranean diet to help curtail dementia,” Shannon concluded.
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