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The Mediterranean diet, charÂacÂterÂized by freÂquent conÂsumpÂtion of vegÂetable-rich meals cooked in olive oil, may proÂtect against high blood presÂsure by comÂbinÂing unsatÂuÂrated fats with nitrite-rich vegÂetaÂbles. Research on mice showed that nitro fatty acids formed from this comÂbiÂnaÂtion can lower blood presÂsure by inhibitÂing an enzyme that regÂuÂlates blood presÂsure, and extra virÂgin olive oil and fresh olives are also natÂural sources of these benÂeÂfiÂcial comÂpounds.

One of the main charÂacÂterÂisÂtics of the Mediterranean diet is the freÂquency of vegÂetable-rich meals and salÂads cooked in plenty of olive oil. And while we know that the addiÂtion of olive oil to vegÂetaÂbles can increase the absorpÂtion of vitÂaÂmins and antioxÂiÂdants, it appears that this powÂerÂful comÂbiÂnaÂtion has another sigÂnifÂiÂcant health effect: it may proÂtect from high blood presÂsure.
A new study pubÂlished in the jourÂnal PNAS, sugÂgests that an eatÂing patÂtern that comÂbines unsatÂuÂrated fats (such as olive oil) with speÂcific vegÂetaÂbles rich in in nitrite and nitrates can proÂtect from hyperÂtenÂsion. Nitrite rich vegÂetaÂbles are mainly green leafy types such as spinach, wild greens, and root vegÂetaÂbles. These vegÂetaÂbles are conÂsumed on a daily basis within a Mediterranean diet and always with olive oil. Researchers found that when these two foods are comÂbined you have the forÂmaÂtion of nitro fatty acids.
For this study, mice were used to examÂine how nitro fatty acids conÂtrol blood presÂsure by inhibitÂing an enzyme that is known to regÂuÂlate blood presÂsure.
The results showed that the mice genetÂiÂcally engiÂneered not to be reacÂtive to this enzyme process had no change in blood presÂsure, while in norÂmal mice the nitro fatty acids lowÂered the blood presÂsure.
The researchers conÂcluded that the comÂmon comÂbiÂnaÂtion of unsatÂuÂrated fatty acids such as olive oil with these vegÂetaÂbles conÂtributes to the proÂtecÂtive action of the Mediterranean diet.
In another study pubÂlished in the jourÂnal PLOS ONE, researchers were able to demonÂstrate by using mass specÂtromÂeÂtry, that extra virÂgin olive oil as well as fresh olives are also a source of nitro fatty acids on their own, thus potenÂtially conÂtributÂing even more to the antiÂhyÂperÂtenÂsive effect.