“The objective of the project is to develop a new intelligent biopesticide based on bacterial spores specifically aimed at eliminating Xylella fastidiosa,” said Julia Manetsberger, a researcher at the University of Cambridge.
Additionally, the study seeks to increase the range of alternative biopesticides for use in agriculture in the European Union.See Also: New Tool Could Stop the Spread of Main Xylella Fastidiosa Vector
Xylella fastidiosa poses a significant challenge for olive farmers in the E.U. It is estimated that the bacteria causes an estimated annual production loss of €5.5 billion, thereby putting more than 300,000 jobs at risk unless its threat is contained.
As a result, the E.U. considers eradicating Xylella fastidiosa a high priority. Unfortunately, previous field treatment attempts have failed, highlighting the need to find a lasting solution to the olive tree menace.
Currently, the availability of natural alternatives is low, which makes the search for new solutions for pests and disease vectors urgent.
Due to these challenges, the study proposes developing new biopesticides based on bacterial spores that specifically target Xylella fastidiosa insect vectors and infected trees.
While using spores is not new in medical applications, the study seeks to extend the concept by engineering spores to be used as a biopesticide delivery vehicle.
To achieve this, the study will isolate the bacterial candidates from vectors and orchards. An activity screen will identify new antimicrobial peptides that target Xylella fastidiosa.
These spores will then be engineered to express and store the active agents in the core or coat them against biological degradation and physicochemical. The heterologous protein will be released into the environment during germination.
“This study will provide novel insights into the treatment of Xylella fastidiosa under field conditions, while also extending our repertoire of alternative biopesticides for use in E.U. agriculture,” the commission wrote. “In a wider context, the project seeks to contribute to transforming E.U. agriculture into a modern, resource-efficient and resilient sector.”